基本信息

姓名：李攀             性别：女

出生年月：1989.09.09    政治面貌：预备党员

电话：15269198069      邮箱：lipan@lcu.edu.cn

教育及工作经历

2017.08-至今            永利总站ylzz55               讲师

2016.06-2017.04         伦敦大学永利总站ylzz55                博士联合培养

2012.09-2017.07         山东大学生命科学学院          硕博连读

2008.09-2012.07         西南民族大学生命科学学院      本科

1.分子生物学领域：运用基因克隆、载体构建、转基因遗传材料获得、代

谢组分分析等一系列分子生物学技术成功地从水稻、苹果、尾虎兰等植物材料中分离得到糖基转移酶基因，并通过体内外实验证明这些糖基转移酶能够糖基化修饰细胞分裂素、黄酮类化合物等一系列药用成分。

1.1发表论文

Pan Li#, Hongjuan Ge#, Lei Zhang#, Jing Shu, Zhuojing Sun, Lepu Jiang, Chengchao Zheng, Huairui Shu, Guangli Sha*, Lusha Ji*, Shizhong Zhang*. Study on the molecular mechanism of apple flavonoid glycosyltransferase gene MdGT1 involved in color of apple leaves. Plant Journal, 2021, doi:10.1101/2021.02.01.429094. SCI一区Top，IF=6.812

Pan Li#, Yanjie Li#, Fengju Zhang, Guizhi Zhang, Xiaoyi Jiang, Huimin Yu, Bingkai Hou*. The Arabidopsis UDP-glycosyltransferases UGT79B2 and UGT79B3 contribute to cold, salt and drought stress tolerance via modulating anthocyanin accumulation. Plant Journal, 2017, 89: 85-103. SCI一区Top, IF=6.812

Pan Li, Yanjie Li, Bo Wang, Huimin Yu, Qin Li, Bingkai Hou*. The Arabidopsis UGT87A2, a stress-inducible family 1 glycosyltransferase,is involved in the plant adaptation to abiotic stresses. Physiologia Plantarum, 2017, 159: 416-432. SCI一区, IF=4.148

Pan Li#, Kang Lei#, Yanjie Li, Xingrui He, Shuo Wang, Renmin Liu, Lusha Ji*, Bingkai Hou*. Identification and characterization of the first cytokinin glycosyltransferase from rice. Rice. 2019, 12(1): 19. SCI一区, IF=3.912

Pan Li#, Kang Lei#, Lin Liu, Guizhi Zhang, Hongjuan Ge, Chengchao Zheng, Huairui Shu, Shizhong Zhang*, Lusha Ji*. Identiication and functional characterization of a new lavonoid synthase gene MdFLS1 from apple. Planta, 2021, 253(5):105. SCI一区, IF=3.390

Pan Li, Weiyue Guo, Kang Lei, Lusha Ji*. Characterization of the complete chloroplast genome of Syzygium nervosum. Mitochondrial DNA Part B: Resources, 2021, 6(3): 1014-1015. SCI四区, IF=0.885

Lusha Ji#, Pan Li#, Zhenhua Su, Meifang Li, Shangjing Guo*. Cold-tolerant introgression line construction and low-temperature stress response analysis for bell pepper. Plant Signaling and Behavior, 2020, 15(7):1773097. SCI三区, IF=1.671

Lusha Ji#, Pan Li#, Zhenhua Su, Meifang Li*. Transcriptome Analysis Reveals Candidate Genes Involved in Low Temperature Stress in Bell Pepper. Russian Journal of Plant Physiology, 2020, 67(6): 1116-1125. SCI四区, IF=1.108

Weiyue Guo#, Pan Li#, Kang Lei, Lusha Ji*. Characterization of the complete chloroplast genome of Sansevieria trifasciata var. Laurentii. Mitochondrial DNA Part B: Resources, 2021, 6(1):198-199. SCI四区, IF=0.885

YanJie Li, Pan Li, Ting Wang, Fengju Zhang, Xuxu Huang, Bingkai Hou*. The maize secondary metabolism glycosyltransferase UFGT2 modifies flavonols and contributes to plant acclimation to abiotic stresses. Annals of Botany, 2018, 122(7): 1203-1217. SCI一区, IF=4.005

Ting Wang, Pan Li, Tianjiao Mu, Guangrui Dong, Chengchao Zheng, Shanghui Jin, Tingting Chen, Bingkai Hou, Yanjie Li*. Overexpression of UGT74E2, an Arabidopsis IBA glycosyltransferase, enhances seed germination and modulates stress tolerance via ABA signaling in rice. International Journal of Molecular Sciences, 2020, 21(19):E7239. SCI二区, IF=4.556

Yanjie Li, Pan Li, Yong Wang, Ruirui Dong, Huimin Yu, Bingkai Hou*. Genome-wide identification and phylogeneticanalysis of Family-1UDP glycosyltransferases in maize (Zea mays). Planta, 2014, 239:1265-1279. SCI一区, IF=3.390

Yanjie Li, Fangfei Liu, Pan Li, Ting Wang, Chengchao Zheng, Bingkai Hou. An Arabidopsis cytokinin-modifying glycosyltransferase UGT76C2 improves drought and salt tolerance in rice. Frontiers in Plant Science, 2020, 11:560696. SCI一区, IF=4.402

Guizhi Zhang, Shanghui Jin, Pan Li, Xiaoyi Jiang, Yanjie Li, Bingkai Hou*. Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis. Plant Cell Reports, 2017, 36(12):1995-2006. SCI一区, IF=3.825.

Tingting Chen, Fangfei Liu, Dongwang Xiao, Xiaoyi Jiang, Pan Li, Shuman Zhao, Bing-Kai Hou, Yan-Jie Li*. The Arabidopsis UDP-glycosyltransferase 75B-1, Conjugates Abscisic Acid and Affects Plant Response to Abiotic Stresses. Plant Molecular Biology, 2020, 102(4-5):389-401. SCI二区, IF=3.302

Guizhi Zhang, Shanghui Jin, Xiaoyi Jiang, Ruirui Dong, Pan Li, Yanjie Li, Bingkai Hou*. Ectopic expression of UGT75D1,a glycosyltransferase preferring indole-3-butyric acid, modulates cotyledon development and stress tolerance in seed germination of Arabidopsis thaliana. Plant Molecular Biology, 2016, 90:77-93. SCI二区, IF=3.302

李星坤,潘慧,李攀,王振,刘林,张桂枝.基于CRISPR/Cas9系统的拟南芥ugt84a1/ugt84a2双突变体制作及突变位点分析. 江苏农业科学, 2020, 48(20):49-55. 中文普通期刊

1.2 主持纵向项目

MdGT1参与苹果新生根寿命和根系长度的耦合机制.32001982, 国家自然科学基金青年基金, 2021/01-2023/12, 24万元, 在研, 主持.

水稻糖基转移酶OsX调节细胞分裂素合成与生长发育的功能研究. ZR2019PC041, 山东省自然科学基金培养基金, 2019/07-2022/06, 5万元,在研, 主持.

1.3 申请发明专利

李攀，冀芦沙. 一种重组苹果黄酮合成酶及其制备方法和用途. 国家发明专利, 专利申请号：202011166253.8.

李攀, 冀芦沙. 水稻糖基转移酶Os6的用途. 国家发明专利, 专利申请号: 201811101467X.

2. 生物制药领域：从天然药用植物中提取有用成分，将其作用于癌症细胞或患癌模型小鼠，检测天然产物药用活性，为将来抗癌药物的制备奠定理论与实践基础；运用化学合成的方法修饰天然化合物，将其作用于植物或动物中，观察植物或动物生长发育特性，再运用生物信息学和分子生物学等技术手段，寻找修饰后天然化合物作用靶点和作用机制。

2.1发表论文

Pan Li, Jing Wang, Lei Zhang, Jinghua Qu, Lin Liu, Yanjie Li, Hongjuan Ge, Lusha Ji*, Shizhong Zhang*. Plant secondary metabolites flavonoids and its glycosylation modification. Planta, 2021, 投稿中. SCI一区, IF=3.390

Pan Li#, Kang Lei#, Jing Wang, Weiyue Guo, Hongjuan Ge, Lusha Ji*, Guangyao Li*. Advanced analysis of mitochondria and identification of key medicinal targets in five Rutaceae plants including grapefruit, orange, citrus. International Journal of Molecular Sciences. 2021, 投稿中. SCI二区, IF=4.512.

Kang Lei#, Pan Li#, Xuefang Yang, Shiben Wang, Xuekun Wang, Xuewen Hua, Bin Sun, Lusha Ji and Xiaohua Xu*. Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action. Journal of Agricultural and Food Chemistry. 2019, 67:10489-10497. SCI一区, IF=3.381

张泽鑫, 李攀, 马晓瑞, 谢芳, 魏洪帅, 朱艳娟, 冀芦沙*. “聊红椿”提取物对非小细胞肺癌的抑制作用. 聊大学报, 2021, 34(1): 104-110. 普通中文期刊

2.2 主持横向项目

多种植物代谢产物提取与分析. 2021/04-2022/04, 20万元, 在研, 主持.

苹果中第一个黄酮糖基转移酶基因的鉴定与功能分析. 2020.01-2021.12, 5万元，在研,主持

2.3 参与项目

国家重点研发计划项目, 用于新型生物药物的稳定剂类药用辅料工艺优化及质量提升

（SQ2020YFF0422322), 2020-10至2020-10, 300万元, 在研, 参与

2.4 参与专利及著作

冀芦沙, 雷康, 李攀. 一种适用于生物发酵罐的固体和液体兼顾的定量补料装置. 实用新型专利, 专利申请号: 202120200185.6.

冀芦沙, 雷康, 李攀. 一种适用于生物发酵罐的固体和液体混合搅拌器装置. 实用新型专利, 专利申请号: 202120200240.1.

冀芦沙, 雷康, 李攀. 一种适用于药用辅料的生物发酵罐. 实用新型专利, 专利申请号: 202120197889.2.

冀芦沙, 雷康, 李攀. 一种产甘氨酸的噬碱性芽孢杆菌发酵优化装置. 实用新型专利, 专利申请号: 202022429239.4.

冀芦沙, 雷康, 李攀. 一种产环糊精的噬碱性芽孢杆菌发酵优化装置. 实用新型专利, 专利申请号: 202022429200.2.

冀芦沙, 雷康, 李攀. 海藻生物活性物质中卤族化合物分离鉴定软件. 软件著作权, 获批编号: 2021SR0258213

冀芦沙, 雷康, 李攀. 海藻生物活性物质中萜类化合物分离鉴定软件. 软件著作权, 获批编号: 2021SR0258210

冀芦沙, 雷康, 李攀. 海藻生物活性物质中溴酚类化合物分离鉴定软件. 软件著作权, 获批编号: 2021SR0257692

冀芦沙, 雷康, 李攀. 海藻生物活性物质中海藻单宁分离鉴定软件. 软件著作权, 获批编号: 2021SR0258247

冀芦沙, 雷康，李攀. 一种海藻多糖与钙配合物偶联预测软件. 软件著作权, 获批编号: 2021SR0258223

冀芦沙, 雷康，李攀. 一种β-环糊精与挥发油类包合能力分析软件. 软件著作权, 获批编号: 2021SR0008209

冀芦沙, 雷康, 李攀. 一种β-环糊精与强心苷类包合能力分析软件. 软件著作权, 获批编号：2021SR0008204

冀芦沙, 雷康, 李攀. 一种β-环糊精与生物碱类包合能力分析软件. 软件著作权, 获批编号：2021SR0008207