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副教授
雷康
作者: 发布日期:2021-05-14

一、基本情况

雷康,男,博士,讲师硕士生导师,2018年获永利总站ylzz55光岳英才称号

通讯地址:山东省聊城市湖南路1

Emai: leikang@lcu.edu.cn

 

二、研究领域

天然源农药和绿色化学农药创制研究

 

三、工作及学习经历

2007.07毕业于泰山学院化学系获学士学位,2010.06毕业于中南大学化学化工学院院所获有机化学硕士学位,2010.07-2013.01就职北京康龙化成新药研发公司2013.05-2013.09就职北京保诺科技,2016.06南开大学农药学博士学位。2016.7-永利总站ylzz55讲师,硕士生导师

 

、教学工作

药品生产质量管理规范》、《生药学》和《药物合成实验

 

、承担课题

1. 含噻嗪结构的新型HPPD抑制类除草剂的设计、合成及构效关系研究,31701827,国家自然科学基金青年基金,2018/01-2020/1224万元,结题,主持。

2. 于天然产物Tenuazonic Acid设计、合成新型绿色生态除草功能分子及构效关系研究,2020M671984,中国博士后基金,2020/07-2022/078万元,在研,主持。

3. 含异喹啉酮结构的新型HPPD酶抑制类除草剂的设计、合成及构效关系研究,318051647,永利总站ylzz55博士启动基金,2017/03至今,8万元,在研,主持。

4. 以角鲨烯环氧化酶CYP51为双靶点的抗真菌抑制剂筛选、设计、合成及活性研究,81703357,国家自然科学基金青年基金,2018/01-2020/1219万元,结题,承担。

5. 具有逆转细菌耐药活性的AcrB抑制剂的研究,2019GSF108051,山东省重点研发计划项目,2019/01-2021/1215万元,在研,承担。

6. 对羟基苯乙酮的制备工艺研究. K19LD1801, 2019/08-2020/08, 6万元, 结题, 主持.

 

、代表性文章及专利

1. Chaochao Wang, Hui Liu, Wei Zhao, Pan Li, Lusha Ji, Renmin Liu, Kang Lei,* Xiaohua Xu. Synthesis and Herbicidal Activity of 5-(1-Amino-2-phenoxyethylidene)barbituric Acid Derivatives, Chin. J. Org. Chem. 2021, DOI: 10.6023/cjoc202010042. (三区,IF=1.34

2. Pan Li,† Kang Lei,† Lin Liu, Guizhi Zhang, Hongjuan Ge, Chengchao Zheng, Huairui Shu, Shizhong Zhang, Lusha Ji.* Identiication and functional characterization of a new lavonoid synthase gene MdFLS1 from apple. Planta, 2021, 253, 105. (三区,IF=3.39

3. Kang Lei,* Pan Li, Xiaoyun Zhou, Shiben Wang, Xuekun Wang, Lusha Ji, Renmin Liu, Xiaohua Xu. Design, synthesis of 5-acylbarbituric acid derivatives and evaluation of herbicidal activity and molecular mode of action. Chin. J. Org. Chem. 2020, 40, 2788−2797.(三区,IF=1.34

4. Kang Lei,* Pan Li, Xuefang Yang, Shiben Wang, Xuekun Wang, Xuewen Hua, Bin Sun, Lusha Ji, Xiaohua Xu. Design and synthesis of novel 4‑hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives for use as herbicides and evaluation of their mode of action. J. Agric. Food Chem. 2019, 67, 10489−10497.(一区,IF=4.19

5. Kang Lei,* Yang Liu, Shiben Wang, Bin Sun, Xuewen Hua, Xiaohua Xu. Synthesis and herbicidal activity of 3-acetyl-4-hydroxy-2,1-benzothiazine derivatives. Chem. Res. Chinese Universities, 2019, 35, 609−615.(三区,IF=1.06

6. Pan Li, Kang Lei, Yanjie Li, Xingrui He, Shuo Wang, Renmin Liu, Lusha Ji, Bingkai Hou.* Identification and characterization of the first cytokinin glycosyltransferase from rice. Rice, 2019, 12, 19.(一区,IF=3.91

7. Xuefang Yang, Kang Lei, Chuihua Kong,* Xiaohua Xu. Effect of allelochemical tricin and its related benzothiazine derivative on photosynthetic performance of herbicide-resistant barnyardgrass. Pestic. Biochem. Phys. 2017, 143, 224230.IF=2.87

8. Kang Lei, Dongwei Sun, Xuewen Hua, Yuanyuan Tao, Xiaohua Xu,* Chuihua Kong. Synthesis, fungicidal activity and structure–activity relationships of 3-benzoyl-4-hydroxylcoumarin derivatives. Pest Manag. Sci. 2016, 72, 13811389.(一区IF=3.80

9. Kang Lei, Xuewen Hua, Yuanyuan Tao, Yang, Liu, Na, Liu, Yi Ma, Yonghong Li, Xiaohua Xu,* Chuihua Kong. Discovery of (2-benzoylethen-1-ol)-containing 1, 2-benzothiazine derivatives as novel 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting-based herbicide lead compounds. Bioorg. Med. Chem. 2016, 24, 92–103.IF=3.07

10. Kang Lei, Dongwei Sun, Yuanyuan Tao, Xiaohua Xu.* A new protocol for total synthesis of natural product frutinone A and its derivatives. Aust. J. Chem, 2016, 69, 98106.四区IF=1.05

11. 雷康,陈珂,王世本,华学文,刘洋,徐效华. 3-(2-芳氧乙酰基)-4-羟基-6-甲基吡喃-2-酮衍生物及其应用,中国发明专利,CN 108570028 A

12. 雷康,柳仁民,周晓芸,王学堃,王世本,陈珂. 3-(1-氨基亚乙基)-6-甲基吡喃-2, 4-二酮衍生物的合成及其作为除草剂的应用,中国发明专利,CN 111072615 A

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